FGF10

FGF10
Наявні структури PDB Пошук ортологів: PDBe RCSB Список кодів PDB 1NUN
Ідентифікатори
Символи	FGF10, fibroblast growth factor 10
Зовнішні ІД	OMIM: 602115 MGI: 1099809 HomoloGene: 3284 GeneCards: FGF10
Пов'язані генетичні захворювання
рак простати, LADD syndrome
Онтологія гена Молекулярна функція • heparin binding • type 2 fibroblast growth factor receptor binding • growth factor activity • GO:0001948, GO:0016582 protein binding • fibroblast growth factor receptor binding • chemoattractant activity • protein tyrosine kinase activity • 1-phosphatidylinositol-3-kinase activity • phosphatidylinositol-4,5-bisphosphate 3-kinase activity Клітинна компонента • extracellular region • клітинне ядро • cell surface • GO:0005578 Позаклітинна матриця • клітинна мембрана • міжклітинний простір • collagen-containing extracellular matrix Біологічний процес • bud outgrowth involved in lung branching • limb bud formation • organ growth • semicircular canal morphogenesis • embryonic pattern specification • bud elongation involved in lung branching • positive regulation of canonical Wnt signaling pathway • muscle cell fate commitment • сльозовиділення • positive regulation of Ras protein signal transduction • positive regulation of urothelial cell proliferation • regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling • limb development • radial glial cell differentiation • female genitalia morphogenesis • mesonephros development • odontogenesis of dentin-containing tooth • prostatic bud formation • blood vessel remodeling • regulation of saliva secretion • Ангіогенез • establishment of mitotic spindle orientation • positive regulation of ERK1 and ERK2 cascade • embryonic digestive tract morphogenesis • animal organ morphogenesis • hair follicle morphogenesis • metanephros development • lung saccule development • lung epithelium development • positive regulation of Notch signaling pathway • negative regulation of cell population proliferation • branch elongation involved in salivary gland morphogenesis • branching involved in salivary gland morphogenesis • positive regulation of white fat cell proliferation • bronchiole morphogenesis • limb morphogenesis • blood vessel morphogenesis • lung development • thymus development • positive regulation of fibroblast proliferation • negative regulation of cell differentiation • ERK1 and ERK2 cascade • positive regulation of epithelial cell migration • positive regulation of mitotic cell cycle • spleen development • smooth muscle cell differentiation • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • positive regulation of Wnt signaling pathway • Harderian gland development • protein localization to cell surface • respiratory system development • epidermis development • positive regulation of peptidyl-tyrosine phosphorylation • metanephros morphogenesis • pancreas development • mammary gland bud formation • positive chemotaxis • mesenchymal-epithelial cell signaling involved in lung development • positive regulation of hair follicle cell proliferation • lacrimal gland development • positive regulation of MAPK cascade • диференціація клітин • positive regulation of keratinocyte proliferation • positive regulation of ATP-dependent activity • positive regulation of epithelial cell proliferation involved in wound healing • epithelial cell differentiation • organ induction • positive regulation of epithelial cell proliferation • epidermis morphogenesis • Загоєння ран • epithelial cell proliferation • regulation of activin receptor signaling pathway • positive regulation of DNA replication • хемотаксис • embryonic genitalia morphogenesis • salivary gland development • positive regulation of keratinocyte migration • response to lipopolysaccharide • thyroid gland development • keratinocyte proliferation • semicircular canal fusion • mammary gland specification • epithelial cell migration • white fat cell differentiation • регуляція експресії генів • lung alveolus development • branching morphogenesis of an epithelial tube • embryonic digestive tract development • lung proximal/distal axis specification • fibroblast growth factor receptor signaling pathway involved in mammary gland specification • actin cytoskeleton reorganization • positive regulation of vascular endothelial growth factor receptor signaling pathway • pituitary gland development • response to estradiol • secretion by lung epithelial cell involved in lung growth • mesenchymal cell differentiation involved in lung development • lung morphogenesis • GO:1904578 response to organic cyclic compound • somatic stem cell population maintenance • tissue regeneration • otic vesicle formation • epithelial cell proliferation involved in salivary gland morphogenesis • cell-cell signaling • male genitalia morphogenesis • GO:1900404 positive regulation of DNA repair • salivary gland morphogenesis • MAPK cascade • embryonic camera-type eye development • induction of positive chemotaxis • urothelial cell proliferation • animal organ formation • fibroblast growth factor receptor signaling pathway • regulation of smoothened signaling pathway • determination of left/right symmetry • inner ear morphogenesis • positive regulation of cell population proliferation • submandibular salivary gland formation • type II pneumocyte differentiation • negative regulation of extrinsic apoptotic signaling pathway in absence of ligand • digestive tract development • regulation of epithelial cell proliferation • epithelial tube branching involved in lung morphogenesis • positive regulation of lymphocyte proliferation • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • phosphatidylinositol phosphate biosynthetic process • phosphatidylinositol-3-phosphate biosynthetic process • peptidyl-tyrosine phosphorylation • regulation of signaling receptor activity • positive regulation of protein kinase B signaling • positive regulation of G1/S transition of mitotic cell cycle Джерела:Amigo / QuickGO
Ортологи
Види	Людина	Миша
Entrez	2255	14165
Ensembl	ENSG00000070193	ENSMUSG00000021732
UniProt	O15520	O35565
RefSeq (мРНК)	NM_004465	NM_008002
RefSeq (білок)	NP_004456	NP_032028
Локус (UCSC)	Хр. 5: 44.3 – 44.39 Mb	Хр. 13: 118.81 – 118.93 Mb
PubMed search
Вікідані
Див./Ред. для людей Див./Ред. для мишей

FGF10 (англ. Fibroblast growth factor 10) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 5-ї хромосоми. Довжина поліпептидного ланцюга білка становить 208 амінокислот, а молекулярна маса — 23 436.

Послідовність амінокислот

10		20		30		40		50
MWKWILTHCA		SAFPHLPGCC		CCCFLLLFLV		SSVPVTCQAL		GQDMVSPEAT
NSSSSSFSSP		SSAGRHVRSY		NHLQGDVRWR		KLFSFTKYFL		KIEKNGKVSG
TKKENCPYSI		LEITSVEIGV		VAVKAINSNY		YLAMNKKGKL		YGSKEFNNDC
KLKERIEENG		YNTYASFNWQ		HNGRQMYVAL		NGKGAPRRGQ		KTRRKNTSAH
FLPMVVHS

A: Аланін
C: Цистеїн
D: Аспарагінова кислота
E: Глутамінова кислота
F: Фенілаланін
G: Гліцин
H: Гістидин
I: Ізолейцин
K: Лізин
L: Лейцин
M: Метіонін
N: Аспарагін
P: Пролін
Q: Глутамін
R: Аргінін
S: Серин
T: Треонін
V: Валін
W: Триптофан

Y: Тирозин

Кодований геном білок за функцією належить до факторів росту. Секретований назовні.

Література

• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 14: 2121—2127. 2004. PMID 15489334 DOI:10.1101/gr.2596504
• Turner N., Grose R. (2010). Fibroblast growth factor signalling: from development to cancer. Nat. Rev. Cancer. 10: 116—129. PMID 20094046 DOI:10.1038/nrc2780
• Milunsky J.M., Zhao G., Maher T.A., Colby R., Everman D.B. (2006). LADD syndrome is caused by FGF10 mutations. Clin. Genet. 69: 349—354. PMID 16630169 DOI:10.1111/j.1399-0004.2006.00597.x

Див. також

• Хромосома 5