Матеріал з Вікіпедії — вільної енциклопедії.
RAC1
Наявні структури
PDB Пошук ортологів: PDBe RCSB
Список кодів PDB
1E96 , 1FOE , 1G4U , 1HE1 , 1HH4 , 1I4D , 1I4L , 1I4T , 1MH1 , 1RYF , 1RYH , 2FJU , 2H7V , 2NZ8 , 2P2L , 2RMK , 2VRW , 2WKP , 2WKQ , 2WKR , 2YIN , 3B13 , 3BJI , 3RYT , 3SBD , 3SBE , 3SU8 , 3SUA , 3TH5 , 4GZL , 4GZM , 4YON , 5FI0
Ідентифікатори
Символи RAC1 Зовнішні ІД
OMIM : 602048 MGI: 97845 HomoloGene: 69035 GeneCards: RAC1
Пов'язані генетичні захворювання
autosomal dominant mental retardation 48 [ 1]
Онтологія гена Молекулярна функція
• histone deacetylase binding • Rho GDP-dissociation inhibitor binding • GTP-dependent protein binding • GO:0006184 GTPase activity • enzyme binding • GO:0001948, GO:0016582 protein binding • thioesterase binding • protein kinase binding • nucleotide binding • GTP binding • protein serine/threonine kinase activity • GO:0032403 protein-containing complex binding • phosphatidylinositol-4,5-bisphosphate 3-kinase activity • ATPase binding
Клітинна компонента
• цитоплазма • гіалоплазма • мембрана • focal adhesion • Меланосома • ruffle membrane • trans-Golgi network • клітинне ядро • cell projection • extrinsic component of plasma membrane • екзосома • lamellipodium • early endosome membrane • клітинна мембрана • мікрофіламент • cytoplasmic ribonucleoprotein granule • endoplasmic reticulum membrane • Golgi membrane • phagocytic cup • GO:0016023 cytoplasmic vesicle • GO:0005578 Позаклітинна матриця • secretory granule membrane • dendritic spine • recycling endosome membrane • postsynapse • glutamatergic synapse • ficolin-1-rich granule membrane
Біологічний процес
• positive regulation of Rho protein signal transduction • regulation of respiratory burst • non-canonical Wnt signaling pathway • positive regulation of protein phosphorylation • positive regulation of actin filament polymerization • regulation of neuron maturation • negative regulation of receptor-mediated endocytosis • platelet activation • Fc-epsilon receptor signaling pathway • cellular response to mechanical stimulus • phagocytosis, engulfment • vascular endothelial growth factor receptor signaling pathway • substrate adhesion-dependent cell spreading • проліферація • ruffle assembly • lamellipodium assembly • dopaminergic neuron differentiation • cell-cell junction organization • Fc-gamma receptor signaling pathway involved in phagocytosis • ruffle organization • actin filament organization • cell motility • anatomical structure morphogenesis • кісткова резорбція • response to wounding • protein localization to plasma membrane • inflammatory response • regulation of small GTPase mediated signal transduction • positive regulation of cell-substrate adhesion • G protein-coupled receptor signaling pathway • neuron projection morphogenesis • epithelial cell morphogenesis • dendrite morphogenesis • regulation of hydrogen peroxide metabolic process • engulfment of apoptotic cell • dendrite development • auditory receptor cell morphogenesis • hyperosmotic response • cerebral cortex GABAergic interneuron development • хемотаксис • positive regulation of DNA replication • actin filament polymerization • адгезія клітин • negative regulation of interleukin-23 production • homeostasis of number of cells within a tissue • cell-matrix adhesion • localization within membrane • actin cytoskeleton organization • regulation of cell size • anatomical structure arrangement • GO:0007243 intracellular signal transduction • regulation of cell migration • ендоцитоз • ephrin receptor signaling pathway • T cell costimulation • зсідання крові • GO:0019049, GO:0030683 mitigation of host defenses by virus • synaptic transmission, GABAergic • mast cell chemotaxis • positive regulation of phosphatidylinositol 3-kinase activity • positive regulation of substrate adhesion-dependent cell spreading • embryonic olfactory bulb interneuron precursor migration • cytoskeleton organization • cochlea morphogenesis • positive regulation of neutrophil chemotaxis • positive regulation of apoptotic process • regulation of cell morphogenesis • positive regulation of focal adhesion assembly • regulation of fibroblast migration • positive regulation of lamellipodium assembly • cerebral cortex radially oriented cell migration • cell migration • semaphorin-plexin signaling pathway • positive regulation of stress fiber assembly • axon guidance • small GTPase mediated signal transduction • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity • Wnt signaling pathway, planar cell polarity pathway • midbrain dopaminergic neuron differentiation • neuron migration • protein phosphorylation • Rho protein signal transduction • regulation of lamellipodium assembly • Rac protein signal transduction • cell projection assembly • positive regulation of microtubule polymerization • neutrophil degranulation • regulation of nitric oxide biosynthetic process • phosphatidylinositol phosphate biosynthetic process • hepatocyte growth factor receptor signaling pathway • regulation of stress fiber assembly • positive regulation of protein kinase B signaling • motor neuron axon guidance • regulation of neutrophil migration • positive regulation of insulin secretion involved in cellular response to glucose stimulus
Джерела:Amigo / QuickGO
Шаблон експресії
Більше даних Ортологи
Види
Людина Миша Entrez Ensembl UniProt RefSeq (мРНК)
RefSeq (білок)
Локус (UCSC)
Хр. 7: 6.37 – 6.4 Mb Хр. 5: 143.49 – 143.51 Mb PubMed search[ 2] [ 3] Вікідані
RAC1 (англ. Ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) ) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 7-ї хромосоми.[ 4] амінокислот , а молекулярна маса — 21 450[ 5]
Послідовність амінокислот
10 20 30 40 50 MQAIKCVVVG DGAVGKTCLL ISYTTNAFPG EYIPTVFDNY SANVMVDGKP VNLGLWDTAG QEDYDRLRPL SYPQTDVFLI CFSLVSPASF ENVRAKWYPE VRHHCPNTPI ILVGTKLDLR DDKDTIEKLK EKKLTPITYP QGLAMAKEIG AVKYLECSAL TQRGLKTVFD EAIRAVLCPP PVKKRKRKCL LL
Кодований геном білок за функцією належить до фосфопротеїнів .
Задіяний у такому біологічному процесі, як альтернативний сплайсинг .
Білок має сайт для зв'язування з нуклеотидами , ГТФ .
Локалізований у клітинній мембрані , цитоплазмі , мембрані.
Drivas G.T., Shih A., Coutavas E., Rush M.G., D'Eustachio P. (1990). Characterization of four novel ras-like genes expressed in a human teratocarcinoma cell line . Mol. Cell. Biol . 10 : 1793—1798. PMID 2108320 doi :10.1128/MCB.10.4.1793 Jordan P., Brazao R., Boavida M.G., Gespach C., Chastre E. (1999). Cloning of a novel human Rac1b splice variant with increased expression in colorectal tumors. Oncogene . 18 : 6835—6839. PMID 10597294 doi :10.1038/sj.onc.1203233 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res . 14 : 2121—2127. 2004. PMID 15489334 doi :10.1101/gr.2596504 Ridley A.J., Paterson H.F., Johnston C.L., Diekmann D., Hall A. (1992). The small GTP-binding protein rac regulates growth factor-induced membrane ruffling. Cell . 70 : 401—410. PMID 1643658 doi :10.1016/0092-8674(92)90164-8 Vincent S., Settleman J. (1997). The PRK2 kinase is a potential effector target of both Rho and Rac GTPases and regulates actin cytoskeletal organization . Mol. Cell. Biol . 17 : 2247—2256. PMID 9121475 doi :10.1128/MCB.17.4.2247 Ren Y., Li R., Zheng Y., Busch H. (1998). Cloning and characterization of GEF-H1, a microtubule-associated guanine nucleotide exchange factor for Rac and Rho GTPases. J. Biol. Chem . 273 : 34954—34960. PMID 9857026 doi :10.1074/jbc.273.52.34954
