VEGFA

VEGFA
Наявні структури
PDB	Пошук ортологів: H0YBI8 PDBe H0YBI8 RCSB
Список кодів PDB
	1BJ1, 1CZ8, 1FLT, 1KAT, 1KMX, 1MJV, 1MKG, 1MKK, 1QTY, 1TZH, 1TZI, 1VGH, 1VPF, 1VPP, 2FJG, 2FJH, 2QR0, 2VGH, 2VPF, 3BDY, 3P9W, 3QTK, 3S1B, 3S1K, 3V2A, 4DEQ, 4GLN, 4GLS, 4KZN, 4QAF, 4WPB, 4ZFF, 5HHC, 5FV1, 5FV2, 5HHD, 5DN2
Ідентифікатори
Символи	VEGFA, MVCD1, VEGF, VPF, vascular endothelial growth factor A
Зовнішні ІД	OMIM: 192240 MGI: 103178 HomoloGene: 2534 GeneCards: VEGFA
Реагує на сполуку
	Brolucizumab
Онтологія гена
Молекулярна функція	• heparin binding; • extracellular matrix binding; • cytokine activity; • growth factor activity; • neuropilin binding; • vascular endothelial growth factor receptor 2 binding; • receptor ligand activity; • vascular endothelial growth factor receptor 1 binding; • protein homodimerization activity; • platelet-derived growth factor receptor binding; • GO:0001948, GO:0016582 protein binding; • vascular endothelial growth factor receptor binding; • fibronectin binding; • chemoattractant activity; • identical protein binding; • protein heterodimerization activity;
Клітинна компонента	• цитоплазма; • мембрана; • extracellular region; • cell surface; • secretory granule; • platelet alpha granule lumen; • міжклітинний простір; • GO:0005578 Позаклітинна матриця;
Біологічний процес	• cardiac vascular smooth muscle cell development; • positive regulation of protein phosphorylation; • positive regulation of MAP kinase activity; • vascular endothelial growth factor signaling pathway; • positive regulation of receptor internalization; • outflow tract morphogenesis; • mammary gland alveolus development; • monocyte differentiation; • cell migration involved in sprouting angiogenesis; • васкулогенез; • positive regulation of retinal ganglion cell axon guidance; • vascular endothelial growth factor receptor signaling pathway; • positive regulation of vascular permeability; • positive regulation of mesenchymal cell proliferation; • Ангіогенез; • positive regulation of blood vessel endothelial cell migration; • positive regulation of ERK1 and ERK2 cascade; • mesoderm development; • positive regulation of positive chemotaxis; • positive regulation of p38MAPK cascade; • positive regulation of neuroblast proliferation; • dopaminergic neuron differentiation; • positive regulation of branching involved in ureteric bud morphogenesis; • розвиток нирки; • lung development; • coronary artery morphogenesis; • in utero embryonic development; • cell maturation; • commissural neuron axon guidance; • positive regulation of peptidyl-serine phosphorylation; • positive regulation of CREB transcription factor activity; • basophil chemotaxis; • artery morphogenesis; • regulation of transcription from RNA polymerase II promoter in response to hypoxia; • positive regulation of peptidyl-tyrosine autophosphorylation; • positive regulation of peptidyl-tyrosine phosphorylation; • branching involved in blood vessel morphogenesis; • positive regulation of protein localization to early endosome; • primitive erythrocyte differentiation; • positive regulation of protein kinase D signaling; • лактація; • диференціація клітин; • epithelial cell differentiation; • positive regulation of leukocyte migration; • positive regulation of epithelial cell proliferation; • negative regulation of apoptotic process; • GO:1901227 negative regulation of transcription by RNA polymerase II; • нейробіологія розвитку; • macrophage differentiation; • positive regulation of angiogenesis; • regulation of retinal ganglion cell axon guidance; • lymph vessel morphogenesis; • post-embryonic camera-type eye development; • regulation of cell shape; • ovarian follicle development; • branching morphogenesis of an epithelial tube; • coronary vein morphogenesis; • surfactant homeostasis; • positive regulation of vascular endothelial growth factor receptor signaling pathway; • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; • response to hypoxia; • positive regulation of endothelial cell proliferation; • positive regulation of protein-containing complex assembly; • positive regulation of protein kinase C signaling; • positive regulation of cell migration; • heart morphogenesis; • platelet degranulation; • positive regulation of axon extension involved in axon guidance; • positive regulation of endothelial cell migration; • multicellular organism development; • positive regulation of histone deacetylase activity; • tube formation; • GO:1901313 positive regulation of gene expression; • positive regulation of protein autophosphorylation; • endothelial cell chemotaxis; • positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway; • positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway; • eye photoreceptor cell development; • positive regulation of transcription from RNA polymerase II promoter in response to hypoxia; • positive regulation of focal adhesion assembly; • cellular response to vascular endothelial growth factor stimulus; • activation of protein kinase activity; • positive regulation of cell division; • camera-type eye morphogenesis; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • positive regulation of cell adhesion; • cellular response to hypoxia; • positive chemotaxis; • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II; • positive regulation of cell population proliferation; • induction of positive chemotaxis; • positive regulation of mast cell chemotaxis; • motor neuron migration; • positive regulation of tyrosine phosphorylation of STAT protein; • ріст; • VEGF-activated neuropilin signaling pathway; • positive regulation of phosphorylation; • regulation of signaling receptor activity; • negative regulation of gene expression; • cytokine-mediated signaling pathway; • positive regulation of cell migration involved in sprouting angiogenesis; • cellular stress response to acid chemical; • positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis; • positive regulation of sprouting angiogenesis; • positive regulation of DNA biosynthetic process; • sprouting angiogenesis; • regulation of nitric oxide mediated signal transduction; • positive regulation of cold-induced thermogenesis; • GO:0072468 сигнальна трансдукція;
	Джерела:Amigo / QuickGO
Шаблон експресії
	; ; ; ;
	Більше даних
Ортологи
	7422
	22339
	ENSG00000112715
	ENSMUSG00000023951
	P15692
	Q00731
NM_003376; NM_001025366; NM_001025367; NM_001025368; NM_001025369;
	NM_001025370; NM_001033756; NM_001171622; NM_001171623; NM_001171624; NM_001171625; NM_001171626; NM_001171627; NM_001171628; NM_001171629; NM_001171630; NM_001204384; NM_001204385; NM_001287044; NM_001317010
NM_001025250; NM_001025257; NM_001110266; NM_001110267; NM_001110268;
	NM_001287056; NM_001287057; NM_001287058; NM_009505; NM_001317041
NP_001020537; NP_001020538; NP_001020539; NP_001020540; NP_001020541;
	NP_001028928; NP_001165093; NP_001165094; NP_001165095; NP_001165096; NP_001165097; NP_001165098; NP_001165099; NP_001165100; NP_001165101; NP_001191313; NP_001191314; NP_001273973; NP_001303939; NP_003367
NP_001020421; NP_001020428; NP_001103736; NP_001103737; NP_001103738;
	NP_001273985; NP_001273986; NP_001273987; NP_001303970; NP_033531
	Вікідані
Див./Ред. для людей	Див./Ред. для мишей

VEGFA (англ. Vascular endothelial growth factor A) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 6-ї хромосоми.^[4] Довжина поліпептидного ланцюга білка становить 232 амінокислот, а молекулярна маса — 27 042^[5].

Послідовність амінокислот

10	20	30	40	50
MNFLLSWVHW	SLALLLYLHH	AKWSQAAPMA	EGGGQNHHEV	VKFMDVYQRS
YCHPIETLVD	IFQEYPDEIE	YIFKPSCVPL	MRCGGCCNDE	GLECVPTEES
NITMQIMRIK	PHQGQHIGEM	SFLQHNKCEC	RPKKDRARQE	KKSVRGKGKG
QKRKRKKSRY	KSWSVYVGAR	CCLMPWSLPG	PHPCGPCSER	RKHLFVQDPQ
TCKCSCKNTD	SRCKARQLEL	NERTCRCDKP	RR

A: Аланін

C: Цистеїн

D: Аспарагінова кислота

E: Глутамінова кислота

F: Фенілаланін

G: Гліцин

H: Гістидин

I: Ізолейцин

K: Лізин

L: Лейцин

M: Метіонін

N: Аспарагін

P: Пролін

Q: Глутамін

R: Аргінін

S: Серин

T: Треонін

V: Валін

W: Триптофан

Y: Тирозин

Кодований геном білок за функціями належить до факторів росту, мітогенів, білків розвитку. Задіяний у таких біологічних процесах, як ангіогенез, диференціація клітин, альтернативний сплайсинг. Білок має сайт для зв'язування з молекулою гепарину. Секретований назовні.

Література

Leung D.W., Cachianes G., Kuang W.-J., Goeddel D.V., Ferrara N. (1989). Vascular endothelial growth factor is a secreted angiogenic mitogen. Science. 246: 1306—1309. PMID 2479986 doi:10.1126/science.2479986
Weindel K., Marme D., Weich H.A. (1992). AIDS-associated Kaposi's sarcoma cells in culture express vascular endothelial growth factor. Biochem. Biophys. Res. Commun. 183: 1167—1174. PMID 1567395 doi:10.1016/S0006-291X(05)80313-4
Lei J., Jiang A., Pei D. (1998). Identification and characterization of a new splicing variant of vascular endothelial growth factor: VEGF183. Biochim. Biophys. Acta. 1443: 400—406. PMID 9878851 doi:10.1016/S0167-4781(98)00240-1
Whittle C.J., Gillespie K.M., Harrison R., Mathieson P.W., Harper S.J. (1999). Heterogeneous vascular endothelial growth factor (VEGF) isoform mRNA and receptor mRNA expression in human glomeruli, and the identification of VEGF148 mRNA, a novel truncated splice variant. Clin. Sci. 97: 303—312. PMID 10464055 doi:10.1042/cs0970303
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 14: 2121—2127. 2004. PMID 15489334 doi:10.1101/gr.2596504
Zhang Z., Henzel W.J. (2004). Signal peptide prediction based on analysis of experimentally verified cleavage sites. Protein Sci. 13: 2819—2824. PMID 15340161 doi:10.1110/ps.04682504