Матеріал з Вікіпедії — вільної енциклопедії.
MUC5B (англ. Mucin 5B, oligomeric mucus/gel-forming ) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 11-ї хромосоми.[ 3] амінокислот , а молекулярна маса — 596 340[ 4]
Послідовність амінокислот
10 20 30 40 50 MGAPSACRTL VLALAAMLVV PQAETQGPVE PSWENAGHTM DGGAPTSSPT RRVSFVPPVT VFPSLSPLNP AHNGRVCSTW GDFHYKTFDG DVFRFPGLCN YVFSEHCRAA YEDFNVQLRR GLVGSRPVVT RVVIKAQGLV LEASNGSVLI NGQREELPYS RTGLLVEQSG DYIKVSIRLV LTFLWNGEDS ALLELDPKYA NQTCGLCGDF NGLPAFNEFY AHNARLTPLQ FGNLQKLDGP TEQCPDPLPL PAGNCTDEEG ICHRTLLGPA FAECHALVDS TAYLAACAQD LCRCPTCPCA TFVEYSRQCA HAGGQPRNWR CPELCPRTCP LNMQHQECGS PCTDTCSNPQ RAQLCEDHCV DGCFCPPGTV LDDITHSGCL PLGQCPCTHG GRTYSPGTSF NTTCSSCTCS GGLWQCQDLP CPGTCSVQGG AHISTYDEKL YDLHGDCSYV LSKKCADSSF TVLAELRKCG LTDNENCLKA VTLSLDGGDT AIRVQADGGV FLNSIYTQLP LSAANITLFT PSSFFIVVQT GLGLQLLVQL VPLMQVFVRL DPAHQGQMCG LCGNFNQNQA DDFTALSGVV EATGAAFANT WKAQAACANA RNSFEDPCSL SVENENYARH WCSRLTDPNS AFSRCHSIIN PKPFHSNCMF DTCNCERSED CLCAALSSYV HACAAKGVQL SDWRDGVCTK YMQNCPKSQR YAYVVDACQP TCRGLSEADV TCSVSFVPVD GCTCPAGTFL NDAGACVPAQ ECPCYAHGTV LAPGEVVHDE GAVCSCTGGK LSCLGASLQK STGCAAPMVY LDCSNSSAGT PGAECLRSCH TLDVGCFSTH CVSGCVCPPG LVSDGSGGCI AEEDCPCVHN EATYKPGETI RVDCNTCTCR NRRWECSHRL CLGTCVAYGD GHFITFDGDR YSFEGSCEYI LAQDYCGDNT THGTFRIVTE NIPCGTTGTT CSKAIKLFVE SYELILQEGT FKAVARGPGG DPPYKIRYMG IFLVIETHGM AVSWDRKTSV FIRLHQDYKG RVCGLCGNFD DNAINDFATR SRSVVGDALE FGNSWKLSPS CPDALAPKDP CTANPFRKSW AQKQCSILHG PTFAACRSQV DSTKYYEACV NDACACDSGG DCECFCTAVA AYAQACHDAG LCVSWRTPDT CPLFCDFYNP HGGCEWHYQP CGAPCLKTCR NPSGHCLVDL PGLEGCYPKC PPSQPFFNED QMKCVAQCGC YDKDGNYYDV GARVPTAENC QSCNCTPSGI QCAHSLEACT CTYEDRTYSY QDVIYNTTDG LGACLIAICG SNGTIIRKAV ACPGTPATTP FTFTTAWVPH STTSPALPVS TVCVREVCRW SSWYNGHRPE PGLGGGDFET FENLRQRGYQ VCPVLADIEC RAAQLPDMPL EELGQQVDCD RMRGLMCANS QQSPPLCHDY ELRVLCCEYV PCGPSPAPGT SPQPSLSAST EPAVPTPTQT TATEKTTLWV TPSIRSTAAL TSQTGSSSGP VTVTPSAPGT TTCQPRCQWT EWFDEDYPKS EQLGGDVESY DKIRAAGGHL CQQPKDIECQ AESFPNWTLA QVGQKVHCDV HFGLVCRNWE QEGVFKMCYN YRIRVLCCSD DHCRGRATTP PPTTELETAT TTTTQALFST PQPTSSPGLT RAPPASTTAV PTLSEGLTSP RYTSTLGTAT TGGPTTPAGS TEPTVPGVAT STLPTRSALP GTTGSLGTWR PSQPPTLAPT TMATSRARPT GTASTASKEP LTTSLAPTLT SELSTSQAET STPRTETTMS PLTNTTTSQG TTRCQPKCEW TEWFDVDFPT SGVAGGDMET FENIRAAGGK MCWAPKSIEC RAENYPEVSI DQVGQVLTCS LETGLTCKNE DQTGRFNMCF NYNVRVLCCD DYSHCPSTPA TSSTATPSST PGTTWILTKP TTTATTTAST GSTATPTSTL RTAPPPKVLT TTATTPTVTS SKATPSSSPG TATALPALRS TATTPTATSV TPIPSSSLGT TWTRLSQTTT PTATMSTATP SSTPETAHTS TVLTATATTT GATGSVATPS STPGTAHTTK VPTTTTTGFT ATPSSSPGTA LTPPVWISTT TTPTTRGSTV TPSSIPGTTH TATVLTTTTT TVATGSMATP SSSTQTSGTP PSLTTTATTI TATGSTTNPS STPGTTPIPP VLTTTATTPA ATSNTVTPSS ALGTTHTPPV PNTMATTHGR SLPPSSPHTV RTAWTSATSG ILGTTHITEP STVTSHTLAA TTGTTQHSTP ALSSPHPSSR TTESPPSPGT TTPGHTTATS RTTATATPSK TRTSTLLPSS PTSAPITTVV TMGCEPQCAW SEWLDYSYPM PGPSGGDFDT YSNIRAAGGA VCEQPLGLEC RAQAQPGVPL RELGQVVECS LDFGLVCRNR EQVGKFKMCF NYEIRVFCCN YGHCPSTPAT SSTAMPSSTP GTTWILTELT TTATTTESTG STATPSSTPG TTWILTEPST TATVTVPTGS TATASSTQAT AGTPHVSTTA TTPTVTSSKA TPFSSPGTAT ALPALRSTAT TPTATSFTAI PSSSLGTTWT RLSQTTTPTA TMSTATPSST PETVHTSTVL TTTATTTGAT GSVATPSSTP GTAHTTKVLT TTTTGFTATP SSSPGTARTL PVWISTTTTP TTRGSTVTPS SIPGTTHTPT VLTTTTTTVA TGSMATPSSS TQTSGTPPSL TTTATTITAT GSTTNPSSTP GTTPIPPVLT TTATTPAATS STVTPSSALG TTHTPPVPNT TATTHGRSLS PSSPHTVRTA WTSATSGTLG TTHITEPSTG TSHTPAATTG TTQHSTPALS SPHPSSRTTE SPPSPGTTTP GHTRATSRTT ATATPSKTRT STLLPSSPTS APITTVVTMG CEPQCAWSEW LDYSYPMPGP SGGDFDTYSN IRAAGGAVCE QPLGLECRAQ AQPGVPLREL GQVVECSLDF GLVCRNREQV GKFKMCFNYE IRVFCCNYGH CPSTPATSST ATPSSTPGTT WILTEQTTAA TTTATTGSTA IPSSTPGTAP PPKVLTSTAT TPTATSSKAT SSSSPRTATT LPVLTSTATK STATSFTPIP SFTLGTTGTL PEQTTTPMAT MSTIHPSSTP ETTHTSTVLT TKATTTRATS SMSTPSSTPG TTWILTELTT AATTTAATGP TATPSSTPGT TWILTEPSTT ATVTVPTGST ATASSTRATA GTLKVLTSTA TTPTVISSRA TPSSSPGTAT ALPALRSTAT TPTATSVTAI PSSSLGTAWT RLSQTTTPTA TMSTATPSST PETVHTSTVL TTTTTTTRAT GSVATPSSTP GTAHTTKVPT TTTTGFTATP SSSPGTALTP PVWISTTTTP TTRGSTVTPS SIPGTTHTAT VLTTTTTTVA TGSMATPSSS TQTSGTPPSL TTTATTITAT GSTTNPSSTP GTTPIPPVLT TTATTPAATS STVTPSSALG TTHTPPVPNT TATTHGRSLP PSSPHTVRTA WTSATSGILG TTHITEPSTV TSHTPAATTS TTQHSTPALS SPHPSSRTTE SPPSPGTTTP GHTRGTSRTT ATATPSKTRT STLLPSSPTS APITTVVTTG CEPQCAWSEW LDYSYPMPGP SGGDFDTYSN IRAAGGAVCE QPLGLECRAQ AQPGVPLREL GQVVECSLDF GLVCRNREQV GKFKMCFNYE IRVFCCNYGH CPSTPATSST ATPSSTPGTT WILTKLTTTA TTTESTGSTA TPSSTPGTTW ILTEPSTTAT VTVPTGSTAT ASSTQATAGT PHVSTTATTP TVTSSKATPF SSPGTATALP ALRSTATTPT ATSFTAIPSS SLGTTWTRLS QTTTPTATMS TATPSSTPET AHTSTVLTTT ATTTRATGSV ATPSSTPGTA HTTKVPTTTT TGFTVTPSSS PGTARTPPVW ISTTTTPTTS GSTVTPSSVP GTTHTPTVLT TTTTTVATGS MATPSSSTQT SGTPPSLITT ATTITATGST TNPSSTPGTT PIPPVLTTTA TTPAATSSTV TPSSALGTTH TPPVPNTTAT THGRSLSPSS PHTVRTAWTS ATSGTLGTTH ITEPSTGTSH TPAATTGTTQ HSTPALSSPH PSSRTTESPP SPGTTTPGHT TATSRTTATA TPSKTRTSTL LPSSPTSAPI TTVVTTGCEP QCAWSEWLDY SYPMPGPSGG DFDTYSNIRA AGGAVCEQPL GLECRAQAQP GVPLGELGQV VECSLDFGLV CRNREQVGKF KMCFNYEIRV FCCNYGHCPS TPATSSTAMP SSTPGTTWIL TELTTTATTT ASTGSTATPS STPGTAPPPK VLTSPATTPT ATSSKATSSS SPRTATTLPV LTSTATKSTA TSVTPIPSST LGTTGTLPEQ TTTPVATMST IHPSSTPETT HTSTVLTTKA TTTRATSSTS TPSSTPGTTW ILTELTTAAT TTAATGPTAT PSSTPGTTWI LTELTTTATT TASTGSTATP SSTPGTTWIL TEPSTTATVT VPTGSTATAS STQATAGTPH VSTTATTPTV TSSKATPSSS PGTATALPAL RSTATTPTAT SFTAIPSSSL GTTWTRLSQT TTPTATMSTA TPSSTPETVH TSTVLTATAT TTGATGSVAT PSSTPGTAHT TKVPTTTTTG FTATPSSSPG TALTPPVWIS TTTTPTTTTP TTSGSTVTPS SIPGTTHTAR VLTTTTTTVA TGSMATPSSS TQTSGTPPSL TTTATTITAT GSTTNPSSTP GTTPITPVLT STATTPAATS SKATSSSSPR TATTLPVLTS TATKSTATSF TPIPSSTLWT TWTVPAQTTT PMSTMSTIHT SSTPETTHTS TVLTTTATMT RATNSTATPS STLGTTRILT ELTTTATTTA ATGSTATLSS TPGTTWILTE PSTIATVMVP TGSTATASST LGTAHTPKVV TTMATMPTAT ASTVPSSSTV GTTRTPAVLP SSLPTFSVST VSSSVLTTLR PTGFPSSHFS TPCFCRAFGQ FFSPGEVIYN KTDRAGCHFY AVCNQHCDID RFQGACPTSP PPVSSAPLSS PSPAPGCDNA IPLRQVNETW TLENCTVARC VGDNRVVLLD PKPVANVTCV NKHLPIKVSD PSQPCDFHYE CECICSMWGG SHYSTFDGTS YTFRGNCTYV LMREIHARFG NLSLYLDNHY CTASATAAAA RCPRALSIHY KSMDIVLTVT MVHGKEEGLI LFDQIPVSSG FSKNGVLVSV LGTTTMRVDI PALGVSVTFN GQVFQARLPY SLFHNNTEGQ CGTCTNNQRD DCLQRDGTTA ASCKDMAKTW LVPDSRKDGC WAPTGTPPTA SPAAPVSSTP TPTPCPPQPL CDLMLSQVFA ECHNLVPPGP FFNACISDHC RGRLEVPCQS LEAYAELCRA RGVCSDWRGA TGGLCDLTCP PTKVYKPCGP IQPATCNSRN QSPQLEGMAE GCFCPEDQIL FNAHMGICVQ ACPCVGPDGF PKFPGERWVS NCQSCVCDEG SVSVQCKPLP CDAQGQPPPC NRPGFVTVTR PRAENPCCPE TVCVCNTTTC PQSLPVCPPG QESICTQEEG DCCPTFRCRP QLCSYNGTFY GVGATFPGAL PCHMCTCLSG DTQDPTVQCQ EDACNNTTCP QGFEYKRVAG QCCGECVQTA CLTPDGQPVQ LNETWVNSHV DNCTVYLCEA EGGVHLLTPQ PASCPDVSSC RGSLRKTGCC YSCEEDSCQV RINTTILWHQ GCETEVNITF CEGSCPGASK YSAEAQAMQH QCTCCQERRV HEETVPLHCP NGSAILHTYT HVDECGCTPF CVPAPMAPPH TRGFPAQEAT AV
Секретований назовні.
Chen Y., Zhao Y.H., Di Y.P., Wu R. (2001). Characterization of human mucin 5B gene expression in airway epithelium and the genomic clone of the amino-terminal and 5'-flanking region. Am. J. Respir. Cell Mol. Biol . 25 : 542—553. PMID 11713095 DOI :10.1165/ajrcmb.25.5.4298 Offner G.D., Nunes D.P., Keates A.C., Afdhal N.H., Troxler R.F. (1998). The amino-terminal sequence of MUC5B contains conserved multifunctional D domains: implications for tissue-specific mucin functions. Biochem. Biophys. Res. Commun . 251 : 350—355. PMID 9790959 DOI :10.1006/bbrc.1998.9469 Desseyn J.-L., Buisine M.P., Porchet N., Aubert J.-P., Laine A. (1998). Genomic organization of the human mucin gene MUC5B: cDNA and genomic sequences upstream of the large central exon. J. Biol. Chem . 273 : 30157—30164. PMID 9804771 DOI :10.1074/jbc.273.46.30157 Desseyn J.-L., Guyonnet-Duperat V., Porchet N., Aubert J.-P., Laine A. (1997). Human mucin gene MUC5B, the 10.7 kb large central exon encodes various alternate subdomains resulting in a super-repeat. Structural evidence for a 11p15.5 gene family. J. Biol. Chem . 272 : 3168—3178. PMID 9013550 DOI :10.1074/jbc.272.6.3168 Keates A.C., Nunes D.P., Afdhal N.H., Troxler R.F., Offner G.D. (1997). Molecular cloning of a major human gall bladder mucin: complete C-terminal sequence and genomic organization of MUC5B. Biochem. J . 324 : 295—303. PMID 9164870 DOI :10.1042/bj3240295 Troxler R.F., Offner G.D., Zhang F., Iontcheva I., Oppenheim F.G. (1995). Molecular cloning of a novel high molecular weight mucin (MG1) from human sublingual gland. Biochem. Biophys. Res. Commun . 217 : 1112—1119. PMID 8554565 DOI :10.1006/bbrc.1995.2884
